Table 3 Comparison of the antagonist effects of A-425619 at TRPV1 responses evoked by different agonist(s). Values are the calculated IC50's and Hill slopes derived from fits of average normalized responses following the concentration-dependent inhibition by the TRPV1 competitive antagonist A-425619.
From: Acidification of rat TRPV1 alters the kinetics of capsaicin responses
ACTIVATOR | IC50 (nM) | Hill Slope |
|---|---|---|
1 μM Capsaicin | 20.1 | -1.1 |
pH 5.5 | 25.9 | -1.2 |
30 nM CAP + pH 5.5 | 23.2 | -1.1 |
100 nM CAP + pH 5.5 | 63.6 | -0.95 |
1 μM CAP + pH 5.5 | 704.0 | -0.93 |