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Table 3 Comparison of the antagonist effects of A-425619 at TRPV1 responses evoked by different agonist(s). Values are the calculated IC50's and Hill slopes derived from fits of average normalized responses following the concentration-dependent inhibition by the TRPV1 competitive antagonist A-425619.

From: Acidification of rat TRPV1 alters the kinetics of capsaicin responses

ACTIVATOR IC50 (nM) Hill Slope
1 μM Capsaicin 20.1 -1.1
pH 5.5 25.9 -1.2
30 nM CAP + pH 5.5 23.2 -1.1
100 nM CAP + pH 5.5 63.6 -0.95
1 μM CAP + pH 5.5 704.0 -0.93