Figure 6
From: Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins
Interaction between TRPV1 and IP receptors at a behavioral level. PGI2-induced thermal hyperalgesia in wild type mice (○, n = 6), TRPV1-/- mice (▲, n = 6) or IP-/- mice (•, n = 6). Thermal hyperalgesia by intraplantar PGI2 (500 pmol/ 20 μL) injection was significantly diminished in TRPV1-/- mice and IP-/- mice. * p < 0.05, ** p < 0.01 vs. wild type mice.