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Figure 3 | Molecular Pain

Figure 3

From: Contrasting phenotypes of putative proprioceptive and nociceptive trigeminal neurons innervating jaw muscle in rat

Figure 3

Contrasting opioid modulation of masseter afferent I Ca . I Ca were elicited by stepping from a holding potential of -90 mV to test potential of 0 mV. A) (i) Example I Ca traces from a trigeminal ganglion masseter afferent recorded in control conditions and in the presence of the μ-opioid agonist DAMGO and the GABA-B receptor agonist baclofen. (ii) A timeplot of the I Ca amplitude at 0 mV for the cell illustrated in (i). Drugs were applied for the duration of the bars. B) (i) Example I Ca traces from a MeV masseter afferent recorded in control conditions and in the presence of the μ-opioid agonist DAMGO the GABA-B receptor agonist baclofen and the I Ca blocker Cd2+. (ii) A timeplot of the I Ca amplitude at 0 mV for the cell illustrated in (i). Drugs were applied for the duration of the bars. C) The response of masseter afferents to a high concentration of DAMGO (3 or 10 μM) is plotted. A reversible inhibition of I Ca of 10% or greater was considered a significant response. Note that cells of all sizes responded to DAMGO, although only 1 MeV masseter afferent was DAMGO sensitive. All MeV masseter afferents were sensitive to baclofen.

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