Single subject pharmacological-MRI (phMRI) study: Modulation of brain activity of psoriatic arthritis pain by cyclooxygenase-2 inhibitor

Table 1 Brain regions activated for palpating painful joints in a psoriatic arthritis patient

Region	Coordinates			Z value	Cluster Index	Voxels	P value
	x	y	z
R sup temporal pole	46	6	-6	6.24	10	835	p < 10^-14
R ant insula *	40	20	-6	3.98	10
R inf parietal, S2 *	42	-22	16	3.93	10
L ant insula *	-42	22	-2	4.66	9	321	p < 10^-06
L ant insula/inf frontal (45/47)	-48	20	-6	4.52	9
R ant thalamus	10	-4	6	3.65	8	258	p < 10^-05
R putamen	26	6	-4	2.70	8
R S1 hand (3) *	44	-20	48	5.43	7	210	p < 10^-04
R S1/M1 hand (3/4)	38	-28	68	4.08	7
R mid temporal	68	-22	8	4.56	6	203	0.000117
bi lingual	-4	-66	10	4.57	5	200	0.000136
R thalamus *	16	-22	8	4.56	4	187	0.000263
mid ACC (24) *	2	22	34	4.48	3	158	0.00122
R SMA (6)	10	-6	52	3.68	2	135	0.00439
L thalamus *	-12	-24	6	4.01	1	123	0.0088

L = left; R = right; bi = bilateral; mid = middle; ant = anterior; inf = inferior; post = posterior; sup = superior ; S1 = primary somatosensory cortex; S2 = secondary somatosensory cortex; M1 = primary motor cortex; ACC = anterior cingulate; SMA = supplementary motor area; numbers in parenthesis = Brodmann areas. Activity for brain areas marked by * are shown in Figure 1C.

ISSN: 1744-8069