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Table 2 Summary of measured changes in spinal cord protein levels. The data presented represent the fold changes in spinal cord protein levels +/- SEM relative to control mice 2 and 48 hours after formalin injection. Some mice received 10 mg/kg morphine one time 30 min prior to formalin injection. *p < 0.05, **p < 0.01, ***p < 0.001. NRD, Not readily detected.

From: Formalin injection causes a coordinated spinal cord CO/NO-cGMP signaling system response

Gene

Formalin (2 hr)

Formalin (48 hr)

Formalin (48 hr)+ Morphine

HO-1

1.00 +/- 0.03

1.03 +/- 0.02

1.02 +/- 0.08

HO-2

1.01 +/- 0.08

1.14 +/- 0.02*

0.92 +/- 0.09

NOS-1

1.05 +/- 0.04

2.29 +/- 0.07***

0.84 +/- 0.13

NOS-2

1.06 +/- 0.06

2.00 +/- 0.11***

1.00 +/- 0.13

NOS-3

1.01 +/- 0.03

1.16 +/- 0.01**

1.05 +/- 0.07

sGCα1

1.00 +/- 0.04

1.24 +/- 0.06**

1.02 +/- 0.05

sGCα2

0.99 +/- 0.03

0.96 +/- 0.01

1.09 +/- 0.03

PKG Iα

0.99 +/- 0.02

1.00 +/- 0.01

1.04 +/- 0.02

PKG Iβ

1.00 +/- 0.05

1.03 +/- 0.01

0.99 +/- 0.02

PKG II

1.01 +/- 0.05

1.17 +/- 0.01*

0.99 +/- 0.08

PDE 2

0.99 +/- 0.04

1.16 +/- 0.01*

1.06 +/- 0.06

PDE 3

NRD

NRD

NRD

PDE 5

0.99 +/- 0.05

1.25 +/- 0.02**

1.00 +/- 0.08