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Figure 2 | Molecular Pain

Figure 2

From: A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord

Figure 2

Effects of ATP and αβmeATP on sEPSCs of lamina I neurons A. The trace on the tope panel shows sEPSCs recorded from a lamina I neuron before and following the application of 100 μM ATP. Two small portions, one before ATP and the other following ATP application (arrows indicated), are shown at the expanded scale. Two histograms below the traces show time courses of sEPSC frequency (left) and amplitude (right) in the same cell. Time bin is 20 sec. B. The bar graph shows pooled results of the effects of ATP (100 μM, n = 44), 10 μM αβmeATP (n = 8), and 100 μM αβmeATP (n = 26) on sEPSC frequency (filled bars) and amplitude (open bars). Data were normalized by the basal levels. C. The bar graph shows effects of capsaicin on sEPSCs in 6 neurons that were tested in B with 100 μM ATP and 100 μM αβmeATP.

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