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Figure 4 | Molecular Pain

Figure 4

From: A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord

Figure 4

Suppression of eEPSCs by ATP and αβmeATP A. The trace on the left shows an averaged eEPSC recorded from a lamina I neuron that received monosynaptic inputs from Aδ-afferent fibers. The averaged eEPSC was obtained from eEPSCs elicited by 10 sweeps of stimuli. The trace on the right is an averaged eEPSC from a lamina I neuron that received monosynaptic inputs from C-fibers. The graph shows numbers of lamina I neurons recorded for all the eEPSC experiments in this study and their corresponding afferent conduction velocity (n = 57). B. Top panel shows superimposed eEPSCs following 10 sweeps of stimuli in normal bath solution (control), following the application of 100 μM ATP, and washout of ATP (recovery). The averaged eEPSCs from 10 sweeps of stimuli are shown in the bottom panel. C. Similar to B except αβmeATP was tested in a different lamina I neuron. D. The bar graph summarizes the increases of synaptic failure rates by 100 μM ATP (black bar, n = 9) and 100 μM αβmATP (gray bar, n = 18). E. A summary of the reduction of average eEPSC amplitude by 100 μM ATP (black bar, n = 9) and 100 μM αβmATP (gray bar, n = 18).

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