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Figure 5 | Molecular Pain

Figure 5

From: A P2X receptor-mediated nociceptive afferent pathway to lamina I of the spinal cord

Figure 5

Suppression of eEPSCs by ATP and αβmeATP in the presence of bicuculline A. The traces show eEPSCs recorded from a lamina I neurons under the following conditions: in bath solution with 20 μM bicuculline (control), following the application of 100 μM ATP in the presence of 20 μM bicuculline, and washout of ATP (recovery). In each set of a test, eEPSCs were elicited by 10 sweeps of stimuli. B. The bar graph shows a pooled result of increases in synaptic failures by ATP (100 μM, n = 5) and αβmeATP (100 μM, n = 6). C. A summary shows the decreases of average eEPSCs by 100 μM ATP (n = 5) and 100 μM αβmeATP (n = 6). All recordings were made from lamina I neurons in the presence of 20 μM bicuculline.

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