Figure 7
From: Pavlovian fear memory induced by activation in the anterior cingulate cortex
Activation of mGluRs in the ACC facilitated escaping behavioral responses in a hot-plate. (a) A diagram explaining a new behavioural escape test using the modified hot-plate instrument. (b) Mice receiving tACPD microinjection into the unilateral ACC 10 min before training showed faster escape response. * P < 0.05 compared with the control group (n = 6 mice, open squares). (c) Extinction responses in control and tACPD-treated groups were similar. MPE were calculated as: (response latency – baseline latency)/(180 – baseline latency). 100% MPE indicates that mouse stayed in the same plate for 3 min without moving into the safe area.