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Figure 2 | Molecular Pain

Figure 2

From: Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats

Figure 2

EPSC-enhancing effect of Forskolin is increased in secondary cells from morphine-tolerant rats. A, Glutamate EPSCs before (control) and during bath application of forskolin (10 μM) in cells from saline control and tolerant rats. B, Time course for the forskolin enhancement of EPSC amplitudes in saline control (n = 12) and tolerant cells (n = 7). The horizontal bar indicates application time for forskolin. C, Normalized EPSC pairs in the absence (control) and presence of forskolin in saline control and tolerant cells. Note forskolin-induced decrease in the PPR of both groups. Forsk, forskolin. * p < 0.05, ** p < 0.01.

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Molecular Pain

ISSN: 1744-8069

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