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Table 1 Summary of previous studies on injury-evoked changes in the induction of LTD

From: Loss of long-term depression in the insular cortex after tail amputation in adult mice

Pain model Species Method Brain region Induction protocol Key findings Reference
Tail amputation Mouse Field potential recording CA1 LFS (1 Hz, 15 min) No effect on LTD induction [45]
LFS (5 Hz, 3 min)
Partial sciatic nerve ligation Mouse Field potential recording CA1 LFS (1 Hz, 15 min) No effect on LTD induction [46]
Digit amputation Rat Field potential recording ACC and parietal cortex LFS (1 Hz, 15 min) Lost LTD in the ACC but not parietal cortex [37]
LFS (5 Hz, 3 min)
Tail amputation Mouse 64-channel field potential recording ACC LFS (1 Hz, 15 min) Rescue of lost LTD by mGluR1 activation [38]
Bone cancer pain Mouse Whole-cell patch-clamp recording ACC Paired training Impaired LTD accompanied by reduced NMDA receptor expression [47]
Tail amputation Mouse 64-channel field potential recording IC LFS (1 Hz, 15 min) Impaired electrical LTD The present study
DHPG-LTD Intact chemical LTD
  1. Notes: ACC, anterior cingulate cortex; DHPG, (RS)-3,5-dihydroxyphenylglycine; IC, insular cortex; LFS, low-frequency stimulation; LTD, long-term depression.