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Table 1 Comparison of mitochondrial area in myelinated and unmyelinated fibers of saphenous nerves obtained from naive wild type (WT) and σ 1 -receptor knockout (σ 1 R-KO) mice and from animals of both genotypes 10 days after treatment with paclitaxel or its vehicle

From: Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice

  

Mean mitocondrial area (μm 2)

Genotype

Treatment

Myelinated

Unmyelinated

WT

Naive

0.102 ± 0.002

0.135 ± 0.016#

Vehicle

0.117 ± 0.008

0.164 ± 0.006##

Paclitaxel

0.134 ± 0.007**

0.161 ± 0.009#

σ 1 R-KO

Naive

0.107 ± 0.005

0.134 ± 0.010#

Vehicle

0.116 ± 0.005

0.164 ± 0.021##

Paclitaxel

0.115 ± 0.006

0.170 ± 0.007##

  1. Values represent the mean mitochondrial area of the results obtained in 3–5 animals per experimental group. Statistically significant differences in comparison to naive WT animals: **P < 0.01 (one way ANOVA followed by Bonferroni test). Note that paclitaxel did not significantly enhance the mean mitochondrial area in σ1R-KO mice myelinated fibers, nor in any genotype in unmyelinated fibers. Statistically significant differences in comparison to myelinated fiber: #P < 0.05; ##P < 0.01 (two way ANOVA followed by Bonferroni test). Note that mitochondrial area was greater in unmyelinated than myelinated fibers in all the experimental groups.
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Molecular Pain

ISSN: 1744-8069

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