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Figure 1 | Molecular Pain

Figure 1

From: ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response

Figure 1

Effect of ARA 290 on mechanical allodynia. A. Effect of spared nerve injury and treatment with vehicle or different doses of ARA 290 on mechanical allodynia. Animals were sham-operated (grey) or received spared nerve injury and 5 doses of vehicle (red), 3 μg/kg ARA 290 (yellow), 10 μg/kg ARA 290 (green), 30 μg/kg ARA 290 (marine blue), or 60 μg/kg ARA 290 (dark blue) administered on days 1, 3, 6, 8 and 10 post-surgery. B. Correlation of ARA 290 treatment dose and the relief of mechanical allodynia, calculated by the difference in area under the curves (AUC) of the mechanical allodynia response on day 1 vs. day 140. The adjusted R2 is 0.56. C. Survival analysis showing the mechanical allodynia-free proportion of animals in time either sham-operated, or receiving spared nerve injury and treated with vehicle or different doses of ARA 290. Log-Rank p < 0.001.

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Molecular Pain

ISSN: 1744-8069

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