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Figure 2 | Molecular Pain

Figure 2

From: ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response

Figure 2

Effect of ARA 290 on cold allodynia. A. Effect of spared nerve injury and treatment with vehicle or different doses of ARA 290 on cold allodynia scores. Animals were sham-operated (grey) or received spared nerve injury and 5 doses of vehicle (red), 3 μg/kg ARA 290 (yellow), 10 μg/kg ARA 290 (green), 30 μg/kg ARA 290 (marine blue), or 60 μg/kg ARA 290 (dark blue) administered on days 1, 3, 6, 8 and 10 post-surgery (for each treatment p < 0.0001 compared to vehicle). Scoring of cold allodynia is described in the Methods Section. B. Correlation of ARA 290 treatment dose and the relief of cold allodynia, calculated by the difference in area under the curves (AUC) of the cold allodynia score on day 1 vs. day 140. The adjusted R2 is 0.78. C. Survival analysis showing the cold allodynia-free proportion of animals in time either sham-operated, or receiving spared nerve injury and treated with vehicle or different doses of ARA 290. Log-Rank p < 0.001.

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Molecular Pain

ISSN: 1744-8069

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