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Figure 3 | Molecular Pain

Figure 3

From: Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

Figure 3

Effects of CK1 inhibitors on carrageenan-induced acute inflammatory pain behaviors. (A, B) Effects of intrathecal injection of IC261 on carrageenan (Car)-induced thermal hyperalgesia. IC261 was injected 5 hour after (A) or 30 min before (B) carrageenan injection. (C, D) Effects of intrathecal injection of TG003 on carrageenan (Car)-induced mechanical allodynia (C) and thermal hyperalgesia (D). Paw withdrawal threshold to mechanical stimulation and paw withdrawal latency to thermal stimuli are plotted against the time after carrageenan injection into a hindpaw. Data are mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, compared with pre-drug data (one-way ANOVA followed by Dunnett’s post hoc test).

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Molecular Pain

ISSN: 1744-8069

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