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Figure 4 | Molecular Pain

Figure 4

From: Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

Figure 4

Effects of CK1 inhibitors on CFA-induced persistent inflammatory pain behaviors. (A, B) Effects of intrathecal injection of IC261 on CFA-induced mechanical allodynia (A) and thermal hyperalgesia (B). (C, D) Effects of intrathecal injection of TG003 on CFA-induced mechanical allodynia (C) and thermal hyperalgesia (D). Paw withdrawal threshold to mechanical stimulation and paw withdrawal latency to thermal stimuli are plotted against the time after intrathecal injection into IC261 or TG003. CFA was injected 3 days before. Data are mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, compared with pre-drug (at 0 hour) data (one-way ANOVA followed by Dunnett’s post hoc test).

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