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Figure 6 | Molecular Pain

Figure 6

From: Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

Figure 6

TG003 decreased the mean frequency, but not the amplitude of sEPSCs in inflammatory pain model mice. Representative traces of sEPSCs in SG neurons of the spinal cord slices from naïve control (A), carrageenan (B)- and CFA (C)-inflamed mice showing the effects of TG003 (1 μM). Lower five traces represent sEPSCs at five given points in time presented above the upper trace, and are shown in an expanded time scale. (D) Summary of results, testing the effects of TG003 on the sEPSC frequencies and amplitudes. The percentage compared to pre-drug response (as 100%) was shown as % control. ** P < 0.01, compared with pretreatment control; # P < 0.05, compared with the effect of IC261 (see Figure 5) (Student’s t test).

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Molecular Pain

ISSN: 1744-8069

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