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Figure 6 | Molecular Pain

Figure 6

From: Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain

Figure 6

The Effect of proton sensing ion channels and P2 receptors antagonists in the induction of thermal hyperalgesia (TH) in acidic saline injected TIIP (AS-TIIP) rats. Graphs showing the effects of Amiloride (a ASICs blocker), AMG9810 (a TRPV1 antagonist), TNP-ATP (a P2X antagonist) and MRS2179 (a P2Y1 antagonist) on acidic injection-induced TH in TIIP rats. Each drug was repetitively injected to the hind paw 30 min before pH 4.0 saline injections (D0-3 post-surgery). Amiloride (A, 30 and 100 nmol), AMG9810 (B, 3 and 10 nmol) and TNP-ATP (C, 100 and 300 nmol) given before pH 4.0 saline injection did not prevent the development of TH (n = 7 in each group). Conversely, repetitive treatment with MRS2179 (D, 100 and 300 nmol, n = 4, 6, 5 in each group) effectively prevented the development of TH in the AS-TIIP group (*p < 0.05, **p < 0.01 vs vehicle).

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Molecular Pain

ISSN: 1744-8069

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