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Figure 3 | Molecular Pain

Figure 3

From: The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

Figure 3

Primary afferent fibre characterisation in compound action potential recordings. A. Representative compound action potential trace recorded from an isolated dorsal root, evoked by 500 μ A stimulation, illustrating the fast (A β), medium (A δ) and slow (C) conducting components (average of 10 traces shown). B. Threshold stimulus intensity of the A β-, A δ- and C-fibre components, which differed significantly with fibre type (P < 0.0001, 1-way ANOVA, n = 9). C. Stimulus response relationship for the C-fibre component. D. 1 Hz stimulation of an isolated dorsal root resulted in a prolongation of latency in the C-, but not A δ-fibre component. Broken lines denote the negative peak of the A δ-/C-fibre response during the first and last stimuli. E. Quantification of the latency prolongation demonstrated that the C-fibre, but not A δ-fibre, component exhibited a significant frequency dependent latency prolongation (A δ vs. C and 1 Hz vs. 2 Hz, P < 0.0001, 2-way ANOVA). All data presented as mean ± SEM. Dotted lines in B. indicate the dorsal root stimulation intensities (A β, 20 μ A; A δ, 100 μ A; C, 500 μ A) used in the subsequent patch-clamp electrophysiology studies. ∗∗∗∗ P < 0.0001.

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