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Figure 5 | Molecular Pain

Figure 5

From: The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

Figure 5

Chemerin does not alter monosynaptic C-fibre eEPSCs in the overall lamina I NK1R+ neuronal population. A. Chemerin (100 ng/ml) does not alter the peak amplitude of monosynaptic C-fibre eEPSCs in control tissue (P = 0.502, chemerin n = 7, vehicle n = 8), although there is a significant decline in peak amplitude over time (P = 0.013). B. In tissue isolated from CFA treated rats, there is no difference in the monosynaptic C-fibre eEPSCs between chemerin and vehicle groups (P = 0.152, chemerin n = 16, vehicle n = 7), although there is a significant reduction in peak amplitude over time (P < 0.0001) and an interaction between these factors (P = 0.0006). All statistics = 2-way repeated measures ANOVA. All data presented as mean ± SEM.

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Molecular Pain

ISSN: 1744-8069

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