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Figure 8 | Molecular Pain

Figure 8

From: The chemerin receptor 23 agonist, chemerin, attenuates monosynaptic C-fibre input to lamina I neurokinin 1 receptor expressing rat spinal cord neurons in inflammatory pain

Figure 8

Chemerin reduces paired-pulse depression of monosynaptic C-fibre input to lamina I NK1R+ neurons. A. Representative EPSC traces evoked by C-fibre paired-pulse stimulation in a chemerin responder recorded before (left, blue trace) and during (right, red trace) chemerin application (average of 6 sweeps shown), where chemerin has increased the paired-pulse ratio/decreased paired-pulse depression. B. In neurons classified as chemerin responders, application of chemerin significantly increases the paired-pulse ratio/decreases paired-pulse depression (P = 0.031, 2-way repeated measures ANOVA, followed by Bonferroni post-tests). Responders n = 5, non-responders n = 6. Data presented as mean ± SEM. ∗ P < 0.05.

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Molecular Pain

ISSN: 1744-8069

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