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Figure 3 | Molecular Pain

Figure 3

From: A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments

Figure 3

Validation of the parameters of SUDO. (A) Strong correlation between mouse paw withdrawal threshold (PWT) estimates calculated using SUDO with 6 von Frey presentations (trials) per test and the method of Chaplan et al. [3]. (B) Correlation between PWT estimates calculated with SUDO using five or six von Frey presentations. (C) Correlation between mouse PWT estimates when calculated as filament bending force using the up-down method of Chaplan et al. and SUDO with 5 von Frey presentations. (D) Effect of changing the adjustment factor for the PWT estimation for SUDO, demonstrating a peak correlation between PWTs calculated using the simplified method and the method of Chaplan et al. [3] with an adjustment factor near 0.5.

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Molecular Pain

ISSN: 1744-8069

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