Figure 6

Protective effects of WIN55,212-2 and AM1710 on paclitaxel-induced mechanical allodynia following drug removal. a. WIN55,212-2 (0.5 mg/kg/day s.c.) suppressed paclitaxel-induced mechanical allodynia 11 days (day 32) following drug removal. b. AM1710 (3.2 and 0.032 mg/kg/day s.c.) suppressed hypersensitivity to mechanical stimulation up to 17 days following drug removal (until day 38). c. AM1710 (3.2 mg/kg/day s.c.) produced a longer duration of protection against paclitaxel-induced mechanical allodynia relative to WIN55,212-2 (0.5 mg/kg/day s.c.). *P < 0.05, **P < 0.01, ***P <0.001 vs. Cremophor-Vehicle, ^# P < 0.05, ^## P <0.01, ^### P <0.001 vs. Taxol-Vehicle, ^⟂ P < 0.05, ^⟂⟂ P < 0.01, ^⟂⟂⟂ P < 0.001 Taxol-Agonist (both doses) vs. Taxol-Vehicle, ^P < 0.05 vs. all groups, ^$ P < 0.05, ^$$$ P < 0.001 Taxol-Agonist (both doses) vs. Cremophor-Vehicle, ^α P < 0.05 Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Cremophor-Vehicle, ⁺ P < 0.05, ⁺⁺ P < 0.01, Taxol-AM1710 (3.2 mg/kg/day s.c.) and Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Taxol-Vehicle, ^ϕ P < 0.05, ^ϕϕ P <0.01 Taxol-AM1710 (3.2 mg/kg/day s.c.) vs. Taxol-Vehicle, ^δ P < 0.05, ^δδ P < 0.01 Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Taxol-Vehicle, ^t P < 0.05, ^tt P < 0.01 Taxol-AM1710 (3.2 mg/kg/day s.c.) and Taxol-WIN55,212-2 (0.5 mg/kg/day s.c.) vs. Cremophor-Vehicle (ANOVA; Dunnett and Tukey post hoc tests). N = 4–8 per group.