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Figure 1 | Molecular Pain

Figure 1

From: Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells

Figure 1

Intrathecal injection of the selective P2Y 6,11 receptor antagonists reverses tactile allodynia. Time course of the antiallodynic effects of the selective P2Y6 (MRS2578, panel A) and P2Y11 (NF340, panel C) receptor antagonists in rats submitted to spinal nerve injury. Data are expressed as mean ± S.E.M. for 6 animals. Withdrawal threshold was assessed 14 days after spinal nerve injury. Dose–response curves of the antiallodynic effect of MRS2578 (10–100 μM, panel B) and NF340 (0.3–30 μM, panel D). Data are expressed as the 50% threshold withdrawal against time curve (AUC). * Significantly different from the vehicle (Veh) group (p < 0.05), as determined by analysis of variance followed by the Student-Newman-Keuls test. N: Naive.

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