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Figure 4 | Molecular Pain

Figure 4

From: Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons

Figure 4

Pharmacological characterization of nicotine evoked currents. A. The fast current was blocked by the non-specific nicotinic receptor antagonist mecamylamine (Mec, top trace), the α7-subunit antagonist MLA (middle trace) and the TRPA1 “selective” antagonist HC-30031 (HC, bottom traces). Currents are from three different neurons in response to nicotine applied with a 5 min inter-stimulus interval before and after the application of antagonist. B. The slow current was also blocked by Mec (top row) but was resistant to MLA (second row) and activated by the α4β3 agonist cytisine (third row). The slow current was also resistant to HC-30031. As in A, current in each row was evoked from a different neuron. All data in A and B were from ART-OE mice, but comparable data for the fast current were obtained from WT mice.

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Molecular Pain

ISSN: 1744-8069

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