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Table 2 nAChR subunit and TRP ion channel mRNA level is reduced in sensory ganglia of Artn and GFRα3 knockout mice

From: Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons

Mouse strain/gene assayed

Fold change trigeminal

Fold change DRG

ART-KO

  

GFRα3

−1.4*

−1.23*

Ret

NC

NC

TRPV1

−1.28*

−1.30*

TRPA1

−1.87*

NC

AChRα3

−2.12*

−1.27*

AChRβ3

−1.58*

−1.54*

AChRβ4

NC

NC

GFRα3-KO

  

TRPV1

−1.56*

−1.51*

TRPA1

NC

−1.30*

AChRα3

−2.61*

−1.27*

AChRβ3

−1.15*

−1.36*

AChRβ4

NC

NC

  1. Fold change in mRNAs using SYBR green RT-PCR analysis of lumbar (L2/3/4) DRGs or TG. N = 3–6 animals per group. NC, not changed. *P < 0.05.