Figure 7

GluA1/3 mediated the potentiation of the AMPAR mediated basal synaptic transmission in ACC-spinal cord projecting neurons. A, Samples and the averaged results showing that NASPM inhibited the AMPAR EPSCs in mice with nerve injury but not in mice with sham surgery. B, Samples and averaged results showing that NASPM only inhibited the AMPAR EPSCs in ACC-SC projecting neurons in mice with nerve injury but not in mice with sham surgery. C, NASPM did not inhibit the AMPAR EPSCs in ACC-VS projecting neurons in mice either with or without nerve injury. D, Plotted figure shows the summarized effect of NASPM on unlabeled or retrograded labeled projecting neurons. E-G, NASPM can only inhibit the AMPAR EPSCs of ACC-SC projecting neurons in s831A mice with nerve injury, but not in s845A mice with nerve injury, as well as s831A and s845A mice with sham surgery. *,p < 0.05; **,p < 0.01; ***,p < 0.001.