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Figure 2 | Molecular Pain

Figure 2

From: Age-dependent sensitization of cutaneous nociceptors during developmental inflammation

Figure 2

Response properties of fast conducting, broad spiking afferents after cutaneous inflammation initiated at P7. A: No changes in mechanical thresholds were found in the fast conducting, broad spiking afferents that were mechanically sensitive (AM) or mechanically and heat sensitive (APM) at any time point after inflammation of the hairy skin initiated at postnatal day 7 (P7). B: However, the heat thresholds of the APM neurons were found to be significantly reduced one and three days after P7 inflammation. Heat thresholds returned to naïve levels by 7d post hairy skin inflammation. C: The mean peak instantaneous frequencies to mechanical deformation of the skin were also found to be significantly increased one day after P7 inflammation in the AM/APM neurons. D: In addition, the mean peak instantaneous frequencies to heat stimuli were enhanced in APMs one day after cutaneous inflammation initiated at P7. *p value <0.05, mean ± SEM; One-way ANOVA with Tukey’s post hoc test for thresholds and Kruskal-Wallis and Dunn’s post hoc test for instantaneous frequencies. See text for animal and afferent numbers.

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