Figure 4

Prevalence of mechanically sensitive, thermally insensitive (CM) and polymodal (CPM) “C”-fibers after inflammation at P7. A: The reduction in the percentage of total CM fibers at P10 in naïve mice was delayed by cutaneous inflammation at P7. The percentage of CM neurons detected three days after P7 inflammation (P10) was not found to be different than the percentage of these cells in naives at P7 or at one day post carrageenan injection (P8). The numbers of CM neurons detected at the three day time point was significantly higher than that detected in time matched naives at P10. By seven days post inflammation (P14), there was no difference in CM fiber prevalence between naives and inflamed mice. B: The normal increase in CPM neuron prevalence at P10 in naïve mice was also delayed by inflammation at P7. The percentage of CPM neurons detected three days after P7 inflammation of the hairy skin was significantly lower than the numbers of CPM neurons found in time matched naives (P10). The increase in CPM neuron prevalence was resolved however by the seven day time point after inflammation (P14). *p value < 0.05 vs P7 and P8 (1d post inflammation); **p value < 0.05 vs time matched naïve controls (P10), χ². See text for animal and afferent totals.