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Figure 8 | Molecular Pain

Figure 8

From: Age-dependent sensitization of cutaneous nociceptors during developmental inflammation

Figure 8

Schematic representation of the age-dependent sensitization of cutaneous sensory neurons during developmental inflammation. Peripheral injury (cutaneous inflammation) sustained prior to the observed critical period (P10; bold) of sensory neuron development (at P7; arrow) specifically results in sensitization of A-fibers (AM/APM; left). Inflammation of the skin after this time point however (at P14; arrow) only sensitizes mechanically sensitive, thermally insensitive (CM) and polymodal (CPM) C-fibers to peripheral stimuli (right). We hypothesize that these unique age-related changes in afferent responsiveness may be due to upregulation of specific genes in the DRGs at the different time points (*).

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