From: Age-dependent sensitization of cutaneous nociceptors during developmental inflammation
Gene | Postnatal Day 7 | Postnatal Day 8 | Postnatal Day 10 | Postnatal Day 14 | Postnatal Day 15 | Postnatal Day 17 | Postnatal Day 21 |
---|---|---|---|---|---|---|---|
trkA | -55 ± 8* | -57 ± 14* | -63 ± 11* | -74 ± 12* | -72 ± 13* | -78 ± 18* | -84 ± 21* |
GFRα1 | 1 + 20 | 56 ± 31 | 75 ± 29* | 101 ± 33* | 102 ± 41* | 49 ± 7* | 67 ± 23* |
GFRα3 | -43 ± 8 | -44 ± 15 | -58 ± 8* | -72 ± 13* | -71 ± 12* | -71 ± 12* | -76 ± 21* |
IGFr1 | 13 ± 35 | 14+ ± 5 | -7 ± 29 | -30 ± 29 | -52 ± 13 | 34 ± 29 | -40 ± 24 |
IL1r1 | 115 ± 20* | 70 ± 21* | 53 ± 15* | 68 ± 44 | 62 ± 18* | 109 ± 20* | -44 ± 20 |
ASIC1 | -7 ± 24 | -14 ± 28 | -20 ± 21 | -35 ± 18 | 57 ± 34 | -27 ± 19 | -45 ± 23 |
ASIC3 | -3 ± 31 | -38 ± 29 | 4 ± 27 | -8 ± 27 | -21 ± 15 | -7 ± 21 | -17 ± 24 |
TRPA1 | 885 ± 30* | 1312 ± 29* | 2196 ± 17* | 2517 ± 19* | 1639 ± 53* | 3014 ± 17* | 2442 ± 23* |
TRPC3 | 53 ± 9* | 57 ± 12* | 27 ± 10 | -22 ± 10 | -41 ± 13 | 11 ± 19 | 7 ± 16 |
TRPM3 | -4 ± 20 | -44 ± 18 | -33 ± 16 | -53 ± 17* | -59 ± 23* | -57 ± 17* | -58 ± 18* |
TRPM6 | 206 ± 26* | 95 ± 23* | 198 ± 18* | 104 ± 25* | 102 ± 26* | 330 ± 27* | 240 ± 20* |
TRPV1 | 111 ± 16* | 60 ± 20# | 60 ± 19# | 36 ± 23 | 34 ± 15 | 25 ± 25 | 35 ± 28 |
P2Y1 | 60 ± 22# | 28 ± 24 | 80 ± 30 | 32 ± 22 | 35 ± 24 | 42 ± 20 | 22 ± 20 |
P2X3 | -7 ± 11 | -16 ± 15 | -44 ± 7* | -50 ± 10* | -64 ± 13* | -59 ± 6* | -57 ± 18* |
Piezo2 | 25 ± 19 | 34 ± 19 | -17 ± 22 | -30 ± 22 | -53 ± 18# | -33 ± 15 | -31 ± 22 |