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Figure 5 | Molecular Pain

Figure 5

From: Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

Figure 5

HO-1 inhibitor SnPP reverses the attenuation of mechanical hyperalgesia by morphine. (A) The withdrawal threshold to mechanical stimuli was examined. *P < 0.001, (DMSO + Mor) compared with (DMSO + PBS), **P < 0.001, (DMSO + Mor) compared with (SnPP + PBS), ***P < 0.001, (DMSO + Mor) compared with (DMSO + Mor) (two-way ANOVA followed by Bonferroni post hoc testing). Data are mean ± SEM (n = 7 for each group). (B) Morphine did not alter expression levels of Hmox-1. *P < 0.05. Each bar represents mean ± SEM (n = 6 for each) Mor; morphine 10 μg, SnPP; tin protoporphyrin 400 nmol.

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