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Figure 6 | Molecular Pain

Figure 6

From: Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

Figure 6

HO-1 inhibitor SnPP blocks morphine-induced phenotype shift of local macrophages. The infiltration of F4/80+iNOS+ M1 macrophages (A) and F4/80+CD206+ M2 macrophages (B) were evaluated on PODs 2 and 7. (C) The numbers of total F4/80, F4/80+iNOS+, and F4/80+CD206+ macrophages were counted. Scale bar, 25 μm. *P < 0.001 (two-way ANOVA followed by Bonferroni post-hoc testing). Each column represents mean ± SEM (n = 6 for each group). Veh; vehicle (PBS + DMSO), Mor; morphine 10 μg, SnPP; tin protoporphyrin 400 nmol.

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Molecular Pain

ISSN: 1744-8069

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