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Figure 7 | Molecular Pain

Figure 7

From: Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

Figure 7

COX inhibitor, indomethacin reverses morphine-induced elevation of mechanical threshold. (A) The withdrawal threshold to mechanical stimuli was examined. *P < 0.05, (Mor + TB) compared with (PBS + TB), **P < 0.05, (Mor + TB) compared with (PBS + Indo), ***P < 0.01, (Mor + TB) compared with (Mor + Indo) (two-way ANOVA followed by Bonferroni post-hoc testing). Data are mean ± SEM (n = 8 for each group). (B) Morphine increased the expression of Ptgs2 at the incised sites. *P < 0.05 (two-way ANOVA followed by Bonferroni post-hoc testing). Each bar represents mean ± SEM (n = 6–9 for each group). TB; tris buffer, Mor; morphine 10 μg, Indo; indomethacin 50 μg, Veh; vehicle (PBS), Nal; naloxone 5 μg.

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Molecular Pain

ISSN: 1744-8069

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