Skip to main content
Figure 8 | Molecular Pain

Figure 8

From: Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway

Figure 8

Indomethacin reverses morphine-induced phenotype switch of macrophages. Infiltration of F4/80+iNOS+ M1 macrophages (A) and F4/80+CD206+ M2 macrophages (B) were evaluated on PODs 2 and 7. (C) The numbers of total F4/80, F4/80+iNOS+, and F4/80+CD206+ macrophages were counted. Scale bar, 25 μm. *P < 0.05, **P < 0.01 (two-way ANOVA followed by Bonferroni post-hoc testing). Each column represents mean ± SEM (n = 6 for each group). Veh; vehicle (PBS + TB), Mor; morphine 10 μg, Indo; indomethacin 50 μg.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us