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Figure 1 | Molecular Pain

Figure 1

From: Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain

Figure 1

Functional effects of different P2X 7 SNPs. A 1 . Concentration-dependent responses to BzATP on HEK-293 cells transfected with WT P2X7 cDNA. Representative example traces for the “pore” formation (top row, Yo-Pro-1 uptake) and the “channel” function (bottom row, Ca2+ flux) assays. Bar scales correspond to 10.000 RFUs. A 2 . Dose response curves for the same experiment shown in A 1 . B, C and D. Example CRCs obtained following application of BzATP for the 3 studied P2X7 SNPs (red symbols) normalized to the responses elicited by the WT variant (black symbols). Averaged data corresponding to multiple experiments are presented in Table  1.

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