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Table 3 Weekly 24 hour average pain severity at baseline

From: Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain

   

All (N = 156)

Male (N = 94)

Female (N = 62)

SNP

SNP ID

MAF

Mean effect

P-value

Mean effect

P-value

Mean effect

P-value

1

rs208294

0.45

0.29

0.062

0.16

0.40

0.50

0.070

2

rs7958311

0.24

-0.10

0.57

-0.20

0.35

0.12

0.73

3

rs28360457

0.022

-0.78

0.13

-0.62

0.24

-2.26

0.15

4

rs1718119

0.36

0.18

0.26

-0.12

0.54

0.63

0.039

5

rs2230911

0.090

-0.12

0.66

-0.040

0.91

-0.35

0.43

6

rs10160951

0.003

0.18

0.90

0.26

0.84

-

-

7

rs2230912

0.13

0.16

0.50

-0.20

0.51

0.63

0.14

8

rs3751143

0.21

0.029

0.88

0.16

0.44

-0.17

0.71

9

rs1653624

0.013

0.38

0.59

0.41

0.53

-

-

  1. Pain was measured by an 11-point Likert scale. Significance of association with P2RX7 SNPs was evaluated under an additive model, adjusted for baseline clinical characteristics in non-Hispanic Caucasian subjects and by gender.
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Molecular Pain

ISSN: 1744-8069

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