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Figure 1 | Molecular Pain

Figure 1

From: Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia

Figure 1

Representative traces of 5 acid-evoked current types in small- to medium-sized muscle afferent dorsal root ganglion (DRG) neurons. (A) In acid-sensing ion channel 3 (ASIC3)-negative, transient receptor potential cation channel V1 (TRPV1)-negative neurons, acid-induced currents were resistant to 500 μM salicylic acid (SA, a selective blocker for ASIC3) and 10 μM capsazepine (CZP, a selective blocker for TRPV1). (B) In ASIC3-positive, TRPV1-negative neurons, acid-induced currents were inhibited by SA but not by CZP. (C) In ASIC3-negative, TRPV1-positive neurons, acid-induced currents were inhibited by CZP but not by SA. (D) In ASIC3-positive, TRPV1-positive neurons, acid-induced currents were inhibited by both SA and CZP. (E) In a small subset of neurons, no acid-induced current was obtained. Numbers are number of neurons to total recorded neurons.

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Molecular Pain

ISSN: 1744-8069

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