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Figure 6 | Molecular Pain

Figure 6

From: Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia

Figure 6

Involvement of Na V 1.8 in acid-induced chronic muscle pain. (A, B) Dual acid injections spaced 2 (A) or 5 (B) days apart induced short-term hyperalgesia (2–4 days) in Na V 1.8−/− mice. (C, D) Analgesic effect of NaV1.8-selective blocker A-803467 was tested at 3 days after mice have developed chronic hyperalgesia induced by dual intramuscular acid injection spaced 5 days apart. The A-803467 (70 mg/kg, i.p.) or vehicle was injected immediately after the baseline response (control) had been obtained. B, baseline on day 0; D, day. Blue and red arrows indicate the time mice receive intraperitoneal injection of vehicle or A-803467 respectively. *P < 0.05 compared with the response before the second acid injection or control.

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