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Table 1 Effect of acid-sensing ion channel 3 (ASIC3) and transient receptor potential cation channel V1 (TRPV1) inhibition on maintenance of hyperalgesia induced by dual acid injections

From: Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia

First injection

Maintenance of hyperalgesia induced by the second acid injection on

 

Day 1

Day 2

Day 5

Acid with APETx2

7 days (20 pmole)

6 days (20 pmole)

4 hr (20 pmole)

3 days (200 pmole)

Acid with capsazepine

9 days

9 days

7 days

Acid with vehicle

>12 days

>12 days

>12 days