Figure 2From: CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy Application of the chemokine SDF-1 increased intracellular calcium concentration in DRG sensory neurons in HFD-induced diabetes. Representative trace of intracellular calcium responses of acutely cultured DRG sensory neurons from RD mice (A) and HFD mice (B) indicating a response to SDF-1 in diabetic DRG. Response to high K + (50 mM) and to capsaicin as positive control is also shown in RD (A) and HFD DRG (B).Back to article page