Skip to main content

Table 1 Neuropeptide and receptor expression in dorsal root ganglia and trigeminal ganglia

From: Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord

 

Dorsal root ganglion

Trigeminal ganglion

Gene symbol and gene name

Mouse TRPV1 lineage RPKM

Mouse non-TRPV1 lineage RPKM

Rat whole ganglion RPKM

Mouse whole ganglion RPKM

Rat whole ganglion RPKM

Human whole ganglion RPKM

Grp, gastrin-releasing peptide

-

-

-

-

-

0.1

Grpr, gastrin releasing peptide receptor

0.2

0.2

-

0.3 ± 0

0.1 ± 0

0.1

Nmb, neuromedin B

170.3

73.7

32.6 ± 4.49

16.5 ± 0.9

13.0 ± 0.3

7.5

Nmbr, neuromedin B receptor

0.1

0.1

0.2 ± 0.02

0.1 ± 0

0.3 ± 0

0.2

Nppa, natriuretic peptide A; ANF

1.5

1.2

5.1 ± 0.73

1.0 ± 0.1

0.8 ± 0.1

1.8

Nppb, natriuretic peptide B; BNP

24.1

0.2

0.7 ± 0.14

2.0 ± 0.1

-

0.8

Nppc, natriuretic peptide C; CNP

-

0.1

-

0.1 ± 0

0.1 ± 0

0.4

Npr1, natriuretic peptide receptor 1; Npra

0.7

1.2

0.8 ± 0.06

1.2 ± 0

0.9 ± 0

0.9

Npr2, natriuretic peptide receptor 2; Nprb

38.1

30

31.7 ± 0.85

35.4 ± 0.4

36.7 ± 0.8

15.3

Npr3, natriuretic peptide receptor 3; Nprc

0.1

0.8

4.1 ± 0.44

2.6 ± 0.1

4.3 ± 0.5

0.3

Tac1, protachykinin-1

597.7

14.1

140.3 ± 10.92

59.8 ± 2.84

122.2 ± 4.9

44.1

  1. The values in the table are average expression levels (and where applicable ± SEM) in RPKM of itch related neuropeptides and their receptors. RPKM is an acronym for Reads Per Kilobase of exon model per Million mapped reads, a normalization which takes into consideration the length of coding exons of genes and depth of sequencing [9]. The mouse DRG dataset consists of TRPV1 lineage and non-TRPV1 lineage RNA samples which were obtained from BAC-TRPV1 promoter-Cre mice as described (Mishra et al., 2011) [6]. Annotation builds mm10, rn4, and hg19 were used, respectively, for the mouse, rat and human genome mapping. Dashes (-) represent values of 20 reads or below; this number of reads is too inaccurate for further consideration.