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Table 2 Neuropeptide and receptor expression in dorsal spinal cord

From: Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord

 

Dorsal spinal cord

Gene symbol and gene name

Mouse RPKM

Rat RPKM

Human RPKM

Grp, gastrin-releasing peptide

1.58 ± 0.71

2.09 ± 0.33

2.93 ± 0.39

Grpr, gastrin releasing peptide receptor

1.34 ± 0.15

0.94 ± 0.10

0.38 ± 0.03

Nmb, neuromedin B

1.28 ± 0.16

0.51 ± 0.08

2.70 ± 0.29

Nmbr, neuromedin B receptor

1.97 ± 0.11

2.02 ± 0.27

2.71 ± 0.72

Nppa, natriuretic peptide A; ANF

0.26 ± 0.03

1.21 ± 0.22

1.02 ± 0.07

Nppb, natriuretic peptide B; BNP

0.02 ± 0.01

0.01 ± 0.01

0.85 ± 0.21

Nppc, natriuretic peptide C; CNP

4.64 ± 0.66

3.61 ± 0.71

54.83 ± 9.74

Npr1, natriuretic peptide receptor 1; Npra

1.75 ± 0.17

5.94 ± 0.46

0.19 ± 0.05

Npr2, natriuretic peptide receptor 2; Nprb

12.46 ± 0.30

19.97 ± 4.90

5.79 ± 0.36

Npr3, natriuretic peptide receptor 3; Nprc

0.77 ± 0.08

0.81 ± 0.13

0.05 ± 0.01

Tac1, protachykinin-1

14.74 ± 1.55

16.14 ± 3.27

70.25 ± 7.60

  1. Average expression levels (±SEM) in dorsal spinal cord of itch-related neuropeptides and their receptors for mouse, rat and human are shown. Detectable expression of Grp, Grpr, Nmb, and Nmbr is seen in all three species. Tac1 is well expressed in spinal cord tissue [24], especially in the human. RPKM levels were determined by Rapid Unified Mapper (RUM) [9]. Annotation builds mm10, rn4, and hg19 were used, respectively, for the mouse, rat and human genome mapping. Dashes (-) represent values of 20 reads or below; this number of reads is too inaccurate for further consideration.
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Molecular Pain

ISSN: 1744-8069

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