Popliteal fossa injection of ciliobrevin D does not influence capsaicin-induced flinching but does affect late mechanical hypersensitivity. A) Popliteal fossa injection of vehicle or ciliobrevin D had no effect on capsaicin (0.9%)-induced nocifensive behaviors whereas lidocaine injection completely blocked the effects of capsaicin. N = 4 - 5 mice per condition. B) Lidocaine completely blocked capsaicin-induced mechanical hypersensitivity whereas ciliobrevin D only had an effect at 3 hrs after capsaicin injection. N = 4 – 5 mice per condition. * = p < 0.05 and *** = p < 0.001.