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Figure 5 | Molecular Pain

Figure 5

From: Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain

Figure 5

Genes from the B2 transcription pattern - similarly spinally and DRG regulated by minocycline. Comparison of the changes in the transcript levels of genes with expression pattern B2 (Rwdd3 and Gimap5) in the lumbar spinal cord using microarray (A, D) and qPCR (B, E) analysis; transcript levels in the DRG (C, F) under neuropathic pain and the modulation by repeated intraperitoneal administration of minocycline (30 mg/kg; i.p. 16 h and 1 h before sciatic nerve damage and then twice daily for 7 days) were also examined using qPCR. The statistical analysis was performed using an ANOVA and Bonferroni’s test. **p <0.01 and ***p <0.001 indicate a significant difference when compared to the control (naïve rats); #p < 0.05, ##p < 0.01 and ###p < 0.001 indicate a significant difference when compared to the V-CCI rats. Naive (N), vehicle (V; water for injection), minocycline (MC).

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