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Figure 4 | Molecular Pain

Figure 4

From: Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

Figure 4

Dose-dependent antinociceptive effects produced by compounds 1–6, oxycodone and 14-OMC. (A) Hot-plate test. (B) Tail-flick test. (C) PPQ abdominal stretching test. Hot-plate and tail-flick latencies (as % MPE) and PPQ-induced stretching response (as % inhibition) were determined as described in Materials and Methods. Data are shown as the mean ± SEM (n = 6–10 mice per group).

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