Skip to main content

Table 1 Binding affinities and selectivities at MOP, DOP and KOP receptors

From: Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

  K i(nM) a Selectivity ratios
  MOP DOP KOP DOP/MOP KOP/MOP
Oxycodoneb 43.6 ± 1.5 1,087 ± 246 2,658 ± 367 25 61
14-OMC 35.3 ± 2.1 116 ± 15 454 ± 6 3 13
1 b 31.7 ± 2.1 498 ± 79 1,648 ± 201 16 52
2 b 2.44 ± 0.13 107 ± 5 364 ± 7 44 149
3 b 5.38 ± 0.42 197 ± 29 378 ± 155 37 70
4 1.61 ± 0.05 28.8 ± 2.3 105 ± 45 18 65
5 0.54 ± 0.04 30.3 ± 2.9 200 ± 40 56 370
6 7.39 ± 0.34 239 ± 40 194 ± 68 32 26
  1. aMembranes from rat brain were used. bData from [30]. Values represent the mean ± SEM of at least three experiments each performed in duplicate.