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Table 1 Binding affinities and selectivities at MOP, DOP and KOP receptors

From: Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor

 

K i(nM) a

Selectivity ratios

 

MOP

DOP

KOP

DOP/MOP

KOP/MOP

Oxycodoneb

43.6 ± 1.5

1,087 ± 246

2,658 ± 367

25

61

14-OMC

35.3 ± 2.1

116 ± 15

454 ± 6

3

13

1 b

31.7 ± 2.1

498 ± 79

1,648 ± 201

16

52

2 b

2.44 ± 0.13

107 ± 5

364 ± 7

44

149

3 b

5.38 ± 0.42

197 ± 29

378 ± 155

37

70

4

1.61 ± 0.05

28.8 ± 2.3

105 ± 45

18

65

5

0.54 ± 0.04

30.3 ± 2.9

200 ± 40

56

370

6

7.39 ± 0.34

239 ± 40

194 ± 68

32

26

  1. aMembranes from rat brain were used. bData from [30]. Values represent the mean ± SEM of at least three experiments each performed in duplicate.