K i(nM) a | Selectivity ratios | ||||
---|---|---|---|---|---|
MOP | DOP | KOP | DOP/MOP | KOP/MOP | |
Oxycodoneb | 43.6 ± 1.5 | 1,087 ± 246 | 2,658 ± 367 | 25 | 61 |
14-OMC | 35.3 ± 2.1 | 116 ± 15 | 454 ± 6 | 3 | 13 |
1 b | 31.7 ± 2.1 | 498 ± 79 | 1,648 ± 201 | 16 | 52 |
2 b | 2.44 ± 0.13 | 107 ± 5 | 364 ± 7 | 44 | 149 |
3 b | 5.38 ± 0.42 | 197 ± 29 | 378 ± 155 | 37 | 70 |
4 | 1.61 ± 0.05 | 28.8 ± 2.3 | 105 ± 45 | 18 | 65 |
5 | 0.54 ± 0.04 | 30.3 ± 2.9 | 200 ± 40 | 56 | 370 |
6 | 7.39 ± 0.34 | 239 ± 40 | 194 ± 68 | 32 | 26 |