Figure 2

The effect of IL-10 mediated by the HSV vectors on the expression of p-p38 in the DRG and the SDH at 2 or 4 weeks. Rats with neuropathic pain were inoculated with QHIL10 or Q0ZHG 1 week post gp120 application with ddC. In the control group, rats received the sham surgery with saline IP injection and Q0ZHG (sham + sal + Q0ZHG). (A and B) Two weeks post vector injection, the L4/5 DRG (A) and the SDH (B) were harvested, and the expression of p-p38 was tested using western blots. The data were analyzed using one way ANOVA with post hoc PLSD test, mean ± SEM, **P < 0.01 vs. control group, # P < 0.05, ## P < 0.01 vs gp120 + ddC + Q0ZHG, n = 4 rats. (C and D) Four weeks post vector injection, the L4/5 DRG (C) and the SDH (D) were harvested, and the expression of p-p38 was tested using western blots. The data were analyzed using one way ANOVA with post hoc PLSD test, mean ± SEM, *P < 0.05, **P < 0.01 vs. control, # P < 0.05, ## P < 0.01 vs gp120 + ddC + Q0ZHG, n = 4 rats.