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Figure 5 | Molecular Pain

Figure 5

From: IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

Figure 5

The effect of IL-10 mediated by the HSV vectors on the expression of CXCR4 in the DRG and the spinal cord at 2 or 4 weeks. Rats with neuropathic pain were inoculated with QHIL10 or Q0ZHG 1 week post gp120 with ddC. In the control group, rats received the sham surgery with saline IP injection and Q0ZHG (sham + sal + Q0ZHG). The data were analyzed using one way ANOVA with post hoc PLSD test, mean ± SEM. (A and B) Two weeks post vector injection, the L4/5 DRG (A) and the SDH (B) were harvested, and the expression of CXCR4 was tested using western blots. **P < 0.01 vs. control, ## P < 0.01 vs gp120 + ddC + Q0ZHG, n = 4 rats. (C and D) Four weeks post vector injection, the L4/5 DRG (C) and the SDH (D) were harvested, and the expression of CXCR4 was tested using western blots. *P < 0.05 vs control, ## P < 0.01 vs. gp120 + ddC + Q0ZHG, n = 4 rats.

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