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Figure 5 | Molecular Pain

Figure 5

From: β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons

Figure 5

Chronic administration of SNC80, not ARM390, results in behavioral symptoms of opioid-induced hyperalgesia in rats, not mice. A & C) Following baseline thermal testing (Pre), separate groups of rats (A) and mice (C) received intraplantar injections once daily for 5 days with SNC80 (20 μg rats, 10 μg mice), ARM390 (20 μg rats, 10 μg mice), or vehicle (4% DMSO, 2% Tween20, PBS). On day 6 (Post), animals were re-tested for thermal sensitivity at least 24 h after the last injection. ***p > 0.001 by two-way ANOVA. B & D) Following thermal testing on day 6, animals received an intraplantar injection of capsaicin (0.5 μg rats, 0.1 μg mice) and nocifensive behavior was quantified for 5 min. **p > 0.01 by one-way ANOVA. n.s. = not significant.

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Molecular Pain

ISSN: 1744-8069

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